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- W2365145828 abstract "OBJECTIVE To investigate the protection of heat shock protein 70 on donor heart and the effects on expression of myocardial cell nitric oxide(NO) and nitric oxide synthase(NOS) of isolated rat heart.METHODS 18 Wistar rats were randomly divided into 2 groups.Control group(C,n = 9),Normal saline 0.5ml was injected intraperitoneally and 24 hours later isolated hearts were stored in 4 ℃ for 3 hours with Histidine-tryptophan-ketoglutarate(HTK) solutions,and then isolated hearts were perfused for 2 hours by Langendorff model.Experimental group(E,n = 9), Noradrenaline Bitartrate 3.1μmol/kg(0.53mg/kg) was injected intraperitoneally and 24 hours later isolated hearts were stored in 4 ℃for 3 hours with HTK,and then isolated hearts were perfused for 2 hours with Krebs-Henseleit(K-H) solutions by Langendorff model.Myocardial HSP70 content,the expression of NO,NOS and related biochemical indicators were detected.RESULTS HSP70,NO and NOS in E group are higher than those in C group and biochemical indicators in E group is better than that in C group.CONCLUSION This study demonstrated that the high expression of HSP70 has obvious protection on donor heart,and it can markedly affect the expression of NO,NOS of isolated rat heart and it is perhaps one of important factors for myocardial protection." @default.
- W2365145828 created "2016-06-24" @default.
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- W2365145828 date "2007-01-01" @default.
- W2365145828 modified "2023-09-24" @default.
- W2365145828 title "Effects of Heat Shock Protein 70 on Myocardial Expression of Nitric Oxide and Nitric Oxide Synthase of Donor Heart" @default.
- W2365145828 hasPublicationYear "2007" @default.
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