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- W2365150511 abstract "Objective:To investigate the anti-proliferation effect of siRNA against survivin combined with DDP on human lung cancer cell line A549.Methods:A549 cells were divided into five different treatment groups:blank control group,pSilencer2.0-NC group,DDP group,pSilencer2.0-SVV2 group,and pSilencer2.0-SVV2+DDP group.LipofectamineTM 2000 was used to transfect A549 cell.The effects on cell proliferation and apoptosis were analyzed by MTT assay,flow cytometry,and TUNEL respectively.The expression of survivin mRNA was evaluated by RT-PCR experiment.Results:The MTT assay indicated that the anti-proliferation rate of pSilencer2.0-SVV2+DDP group was 51.38%±1.35%.The anti-proliferation rate of this group was higher than any other group(P0.05).The experiment of RT-PCR showed that the expression of survivin mRNA in pSilencer2.0-SVV2 group and pSilencer2.0-SVV2+DDP group werelowerthan thatin othergroups(P0.05),butitslevel in blank control group,pSilencer2.0-NC group,DDP group had no marked change(P0.05).Flow cytometry and TUNEL indicated that the apoptosis rates of pSilencer2.0-SVV2+DDP were 42.48%±2.28%and 40.65%± 3.53%respectively,higher than in any other group(sP0.05).Conclusion:siRNA against survivin combined with DDP can enhance the inhibitory effect on lung cancer cell line A549 and induce apoptosis in common." @default.
- W2365150511 created "2016-06-24" @default.
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- W2365150511 date "2009-01-01" @default.
- W2365150511 modified "2023-09-27" @default.
- W2365150511 title "Empirical study on the anti-proliferation effect of siRNA against survivin combined with DDP on human lung cancer cell line A549" @default.
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