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- W2365176316 abstract "Objective To study the cerebral hemodynamic changes after thrombolytic treatment in patients with acute cerebral infarction.Methods Fifty-five patients with acute onset of cerebral infarction within6hours were received intravenous injection of75to150myria-unit urokinase.All cases were scored with Chinese Stroke Scales(CSS)and the cerebral hemodynamic changes were assessed by measuring blood flow velocity in unilateral and contralateral arteries with three dimensional transcranial Doppler(TCD)before and after thrombolytic treatment.The therapeutic effects were evaluated by the improving patterns of neuro-function after treatment in1hour.Re sults The therapeutic effect were significant in40patients(40/55,72.7%)and not significant in15patients(15/55,27.3%)after thrombolysis.The abnormal TCD findings were found in37cases(37/40,92.5%)in significantly effective group and15cases(15/15,100%)in not signifi-cantly effective group.Reducing rate or signal disappeared in cerebrovascular blood flow of infarction side,significant increasing or normal blood flow rate and signal enhanced in opposite of infarction and vertebro-basal artery were found in all of the patients before treatment with thrombolysis.Vascular murmur and turbu-lent flow were found in some patients.One hour after treatment,the blood flow rate and vascular amount in-creased in infarction side compared to that before treatment with significant difference(P0.05or P0.01,respectively),and there were reducing rate of blood flow in vertebro-basal artery and brain opposite to infarc-tion side in significantly effective group.There were no dis tinct change in not significantly effective group.Seven patients with recurrent cerebral infarction were found in significantly effective group after thrombolysis within24hours.Con clu sion The pre-and post-therapeutic cerebro-hemodynamic changes during throm-bolysis in acute cerebral infarction can be objectively evaluated with TCD and also be adopted as the para-menters for evaluating the therapeutic effect or predicting the vascular reocclusion.[" @default.
- W2365176316 created "2016-06-24" @default.
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- W2365176316 date "2003-01-01" @default.
- W2365176316 modified "2023-09-27" @default.
- W2365176316 title "The hemodynamic changes after thrombolysis in acute cerebral infarction" @default.
- W2365176316 hasPublicationYear "2003" @default.
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