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- W2365179959 abstract "Objective Study on the biological efficacy on different degree of PEG modified rhIL-6.Methods Purified rhIL-6 is modified by PEG2-NHS.Mono-PEG-rhIL-6 and di-PEG-rhIL-6 are separated and collected by SEC-HPLC.The determination of IL-6 biological activity is the standard method,namely,7TD1 cells/MTT assay.Reference is calibrated rhIL-6.In vivo: Cyclophosphamide-induced BALB/c mice were divided into model group,positive control group,mono-PEG-rhIL-6 high-dose group,mono-PEG-rhIL-6 low dosage group;di-PEG-rhIL-6 high dosage group,di-PEG-rhIL-6 low dosage group.PEG-rhIL-6 or controls were injected once a day in each group according to the above dosing for 5 days.From third day each group were given cyclophosphamide intra-peritoneal,injection one time daily,continuing 3 days.At the first day of administration and the 8th,11th,14th,17th day,cut tail end for blood.Platelet counts were measured and statistically analyzed.Results In vitro,The detection showed that mono-PEG-rhIL-6 and di-PEG-rhIL-6 or multi-PEG-rhIL-6 have similar activities.But all of them are less than that rhIL-6 by 10 times.In vivo activity assay,the positive control group (rhIL-11),mono-PEG-rhIL-6 and di- or multi-PEG-rhIL-6,high- and low-dose mice platelet count recovery rate are faster than the same period model group.There are significant differences (P 0.05).Conclusions In vitro,mono-PEG-rhIL-6 and di-PEG-rhIL-6 or multi-PEG-rhIL-6 can stimulant 7TD1 cell proliferation.Mono-PEG-rhIL-6 and di-PEG-rhIL-6 can remit the thrombocytopenia induced by cyclophosphamide.So mono-PEG-rhIL-6 and multi-PEG-rhIL-6 (≥ 2) are all the main active ingredients of the drug." @default.
- W2365179959 created "2016-06-24" @default.
- W2365179959 creator A5046003064 @default.
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- W2365179959 date "2010-01-01" @default.
- W2365179959 modified "2023-09-28" @default.
- W2365179959 title "The efficacy of Pegylated recombinant human interleukin-6" @default.
- W2365179959 hasPublicationYear "2010" @default.
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