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- W2365185890 abstract "The effects of Oxytropis ochrocephala alkaloid on rat yolk sac (YS) placenta and embryo development in vitro were investigated by using the whole embryo culture (WEC) method and electron microscopy.The results showed that the alkaloid caused remarkable retardation of YS blood vessel differentiation and embryo development at dose of over 50 μg/mL.Dose dependent relationship was noticed.At concentration of 200 μg/mL,YS diameter was lower than that of control group,and malformation embryo numbers were larger than that of control group.Many pathological changes of the YS ultramicrostructure were observed at dose of over 50 μg/mL.The major changes include sparse and short and loose microvilli of endodermal epithelium cells,a reduction in apical microvesicles and subapical storage vacuoles,swilling of the mitochondria and a reduction or disappear in its cristea,a decrease in rough endoplasmic reticulum,abnormation in pattern and structure of nucleus,an increased vacuolation in cells,an extend in the interval of adjacent cells.The results indicated that blood vessel differentiation and ultramicrostructre of YS were sensitive to the alkaloid.Damage of YS had a high bearing on retardation of embryo development.The injuries of structure and barrier to function of YS placenta was an important mechanism of the alkaloid that caused embryo developmental toxicity." @default.
- W2365185890 created "2016-06-24" @default.
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- W2365185890 date "2003-01-01" @default.
- W2365185890 modified "2023-09-23" @default.
- W2365185890 title "Effects of Oxytropis ochrocephala alkaloid on structure and function of rat yolk sac placenta in vitro" @default.
- W2365185890 hasPublicationYear "2003" @default.
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