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- W2365190497 abstract "Objective To analyze quantitatively fine-structures of hippocampal CA1 axospinous synapses in aged mouse in order to provide the neuroanatomical evidence for the aged-associated learning and memory impairments.Methods Golgi impregnation,consecutive ultrathin sections and NIH imaging software were mainly used to measure spine density,size of spine head and postsynaptic density in hippocampal CA1 axospinous synapses.Results The spine densities of the secondary or tertiary apical dendrites of hippocampal CA1 at 3-month group and 22-month group were(1.056±0.049) and(0.868±0.038)μm~(-1) respectively,with significant difference.There were significant difference in the proportion of the perforated synapses(3-month: 12.7%,22-month:19%) between two groups.Conclusions The decreased axospinous synapses and the increased proportion of the perforated axospinous in hippocampal CA1 of aged mice are probably morphological basis in the aged-associated learning and memory impairments." @default.
- W2365190497 created "2016-06-24" @default.
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- W2365190497 date "2006-01-01" @default.
- W2365190497 modified "2023-09-25" @default.
- W2365190497 title "Quantitative analysis of fine-structures of hippocampal CA1 axospinous synapses in aged mouse" @default.
- W2365190497 hasPublicationYear "2006" @default.
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