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- W2365207130 abstract "【Objective】To explore the relationship between the expression levels of UPA/UPAR mRNA and UPA/UPAR protein in the nasopharyngeal carcinoma tissues and the genesis,development,invasion and metastasis.【Methods】To detect the expression levels ofUPA/UPAR mRNA and UPA/UPAR protein in tissues by using in situ hybridization and flow cytometry system for the chronic nasopharyngitis group(20 cases),nasopharyngeal carcinoma without lymph node metastasis(20 cases),nasopharyngeal carcinoma only withlymph node(20 cases) and nasopharyngeal carcinoma with distal metastasis(20 cases).【Results】The expression levels of UPA/ UPAR mRNA and UPA/ U-PAR protein the nasopharyngeal carcinoma with distal metastasis,the nasopharyngeal carcinoma only with lymph node,the nasopharyngeal carcinoma without lymph node and the chronic nasopharyngitis(P0.05).There were statistical significance with comparison between the UPA protein and UPAR protein in each of two groups(P0.01).There was a significant statistical correlation between UPA protein and UPAR protein in each group(P0.01).【Conclusions】 The change of expression levels of UPA/UPAR mRNA and UPA/UPAR protein were found,which accompanying with the invasion and metastasis in nasopharyngeal carcinoma.Overexpression of UPA and UPAR may play an important role in the invasion and metastasis of the nasopharynaeal carcinoma,and show the poorest prognosis." @default.
- W2365207130 created "2016-06-24" @default.
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- W2365207130 date "2010-01-01" @default.
- W2365207130 modified "2023-09-25" @default.
- W2365207130 title "Expression of UPA and UPAR and their clinical significance in Nasopharyngeal Carcinoma" @default.
- W2365207130 hasPublicationYear "2010" @default.
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