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- W2365210557 abstract "Objective To detect HIV-1RNA and p24 antigen in the liver biopsy specimens of people living with HIV/AIDS.Methods The p24 antigen and HIV-1RNA of liver biopsy samples of 14 patients with HIV/AIDS were examined by immunohistochemistry and in situ hybridization,respectively.Result Intracellular expression of p24 antigen was detected in Kupffer cells,lymphocytes,endothelial cells and hepatocytes of all specimens.In the in situ hybridization test,Kupffer cells and lymphocytes were labeled in all specimens.Furthermore,in 4 specimens the morphology of the HIVRNA positive cells was reproducidly consistent with that of hepatocytes.Conclusion These findings indicate that HIV-1 could replicate in the liver of HIV-infected individuals and might be related to the damaged liver cells." @default.
- W2365210557 created "2016-06-24" @default.
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- W2365210557 date "2009-01-01" @default.
- W2365210557 modified "2023-09-23" @default.
- W2365210557 title "Detection of HIV-1 RNA and p24 antigen in HIV1-infected human liver" @default.
- W2365210557 hasPublicationYear "2009" @default.
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