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- W2365219897 abstract "This work studied the effects of diethylcarbamazine citrate (DEC) on the contraction of isolated thoracic aortic ring of guinea-pig.DEC could markedly inhibit the contraction of thoracic aortic rings induced by KCl and norepinephrine(NE) in a concentration-dependent manner,shifted the cumulative dose-response curves of KCl and NE to right,and reduced the maximal efficacy of contraction in a nonCompetitive antagonistic manner.The pD'2 values of KCl and NE were 1.991 and 2.271 respectively.The further studies of contractive mechanism indicated that DEC inhibited both the Ca2+ release from intracellar storage sites and the influx of extracellar calcium significantly.These results suggest that DEC inhibits vascular contraction through its calcium-antagonistic effect." @default.
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- W2365219897 date "1996-01-01" @default.
- W2365219897 modified "2023-09-25" @default.
- W2365219897 title "Effects of diethylcarbamazine citrate on isolated thoracic aortic ring of guinea-pig" @default.
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