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- W2365227760 abstract "Aim:To observe the effects of allitridum on platelet adhesion after endothelial denudation of iliac artery and approach its mechanism.Methods: The endothelial cells of rabbit's iliac artery were denudated by balloon endothelial denudation.Rabbits of allitridum group were injected with the mixture of 2 ml allitridum injection(contained 30 mg allitridum) and 40 ml normal saline through the auricular vein,and control group were injected only with normal saline.The plasma concentrations of superoxide dismutase(SOD),lipid peroxide(LPO),prostacyclin(PGI2),thromboxane(TXA2),and cyclic adenosine monophosphate(cAMP) were simultaneously determined when the experiment was finished.The platelet adhesion of iliac artery wall was quantified by means of combining scanning electron microscopy with imaging microscopic analysis.Results: The plasmic level of SOD,PGI2,PGI2/TXA2 and cAMP in allitridum group were higher than those in control group(P0.05 ~0.01),while the plasmic level of LPO and TXA2 in allitridum group were lower than control group(P0.05 ~0.01).The number of platelet adhesion of iliac artery wall was decreased with scanning electronic microscopy in allitridum group(9.19±2.84)×105/cm2 compared with control group(15.4±4.34)×105/cm2(P 0.01).Conclusion:Allitridum can inhibit platelet adhesion after endothelial denudation of rabbit's iliac artery through several mechanisms." @default.
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- W2365227760 date "2011-01-01" @default.
- W2365227760 modified "2023-09-25" @default.
- W2365227760 title "The effects of allitridum on the platelet adhesion after balloon endothelial denudation of iliac artery in rabbits" @default.
- W2365227760 hasPublicationYear "2011" @default.
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