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- W2365228534 abstract "Objective To observe the effect of adefovir dipivoxil on T lymphocyte subsetes the treatment of HBeAg-positive chronic hepatitis B.Methods Totally 57 patients with HBeAg-positive chronic hepatitis B were treated with adefovir dipivoxil 10 mg/d for 48 weeks.The T lymphocyte subset in peripheral blood was analyzed by FCM before and after treatment for 3 and 6 months.Results The inferior T lymphocyte subsetes in peripheral blood correlated with the high level of pretreatment HBV-DNA(107copies/ml)(P0.05).CD3+,CD4+,the ratios of CD4+/CD8+ rose and CD8+ descended after treated with adfovir dipivoxil for 24 weeks,which had no statistic difference(P0.05) but CD3+(P0.05).The com-parison of T lymphocyte subsetes in peripheral blood before treatment between the patients who had a negative conversion of HBV-DNA and the patients who hadn’t there was no statistic difference(P0.05).Conclusion The level of HBV-DNA correlated with the abnomality of T lymphocyte subsetes in pe-ripheral blood in patients with HBeAg-positive chronic hepatitis B.Adfovir dipivoxil could improve the abnormality of T lymphocyte subset in peripheral blood in patients with HBeAg-positive chronic hepati-tis B in a certain extent." @default.
- W2365228534 created "2016-06-24" @default.
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- W2365228534 date "2008-01-01" @default.
- W2365228534 modified "2023-09-28" @default.
- W2365228534 title "The Effect of Adefovir Dipivoxil on T Lymphocyte Subsetes in Patients with HBeAg-positive Chronic Hepatitis B" @default.
- W2365228534 hasPublicationYear "2008" @default.
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