Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365237761> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2365237761 abstract "Objective:To research the expression of anti-apoptotic gene Bag-1 in precancerous lesion of breast cancer and the expression levels of Bcl-2 and Bax,explore the correlation between Bag-1 and Bcl-2,Bax,evaluate its clinical significance.Methods:Immunohistochemical SP method was used to detect the expression levels of Bag-1,Bcl-2,and Bax in 15 specimens of breast flat epithelial atypia(FEA),20 specimens of breast ductal carcinoma in situ(DCIS),20 specimens of breast invasive ductal carcinoma(IDC),and 20 specimens of normal breast tissue;the clinicopathological data of all the patients were collected for statistical analysis.Results:The positive expression rates of Bag-1,Bcl-2,and Bax in 15 specimens of breast FEA,20 specimens of breast DCIS,20 specimens of breast IDC,and 20 specimens of normal breast tissue were 33.3%,33.3%,20.0%;70.0%,30.0%,50.0%;70.0%,50.0%,65.0%;25.0%,30.0%,10.0%,respectively.The positive expression rate of Bag-1 in breast FEA was significantly lower than those in breast IDC and breast DCIS(P0.05),the positive expression rate of Bag-1 in normal breast tissue was significantly lower than those in breast IDC and breast DCIS(P0.01).The positive expression rate of Bax in breast FEA was significantly lower than that in breast IDC(P0.01),the positive expression rate of Bax in normal breast tissue was significantly lower than those in breast IDC and breast DCIS(P0.01).There was a positive correlation between positive expression rate of Bag-1 and positive expression rate of Bcl-2 in breast FEA(P0.01).In breast DCIS,there was a positive correlation between positive expression rate of Bag-1 and positive expression rate of Bax,and there was also a positive correlation between positive expression rate of Bcl-2 and positive expression rate of Bax(P0.01).Conclusion:Bag-1 and Bcl-2 can promote each other in the course of malignant transformation from breast FEA to breast cancer,the occurrence and development of breast cancer is regulated by multiple genes,multiple factors affect the proliferation of tumor." @default.
- W2365237761 created "2016-06-24" @default.
- W2365237761 creator A5008695404 @default.
- W2365237761 date "2012-01-01" @default.
- W2365237761 modified "2023-09-26" @default.
- W2365237761 title "Expression and significance of BAG-1 gene in precancerous lesion of breast cancer" @default.
- W2365237761 hasPublicationYear "2012" @default.
- W2365237761 type Work @default.
- W2365237761 sameAs 2365237761 @default.
- W2365237761 citedByCount "0" @default.
- W2365237761 crossrefType "journal-article" @default.
- W2365237761 hasAuthorship W2365237761A5008695404 @default.
- W2365237761 hasConcept C121608353 @default.
- W2365237761 hasConcept C126322002 @default.
- W2365237761 hasConcept C142724271 @default.
- W2365237761 hasConcept C143998085 @default.
- W2365237761 hasConcept C204232928 @default.
- W2365237761 hasConcept C2780862961 @default.
- W2365237761 hasConcept C2781283455 @default.
- W2365237761 hasConcept C3018521938 @default.
- W2365237761 hasConcept C3020109028 @default.
- W2365237761 hasConcept C530470458 @default.
- W2365237761 hasConcept C71924100 @default.
- W2365237761 hasConceptScore W2365237761C121608353 @default.
- W2365237761 hasConceptScore W2365237761C126322002 @default.
- W2365237761 hasConceptScore W2365237761C142724271 @default.
- W2365237761 hasConceptScore W2365237761C143998085 @default.
- W2365237761 hasConceptScore W2365237761C204232928 @default.
- W2365237761 hasConceptScore W2365237761C2780862961 @default.
- W2365237761 hasConceptScore W2365237761C2781283455 @default.
- W2365237761 hasConceptScore W2365237761C3018521938 @default.
- W2365237761 hasConceptScore W2365237761C3020109028 @default.
- W2365237761 hasConceptScore W2365237761C530470458 @default.
- W2365237761 hasConceptScore W2365237761C71924100 @default.
- W2365237761 hasLocation W23652377611 @default.
- W2365237761 hasOpenAccess W2365237761 @default.
- W2365237761 hasPrimaryLocation W23652377611 @default.
- W2365237761 hasRelatedWork W2347496358 @default.
- W2365237761 hasRelatedWork W2352441630 @default.
- W2365237761 hasRelatedWork W2353114984 @default.
- W2365237761 hasRelatedWork W2356310569 @default.
- W2365237761 hasRelatedWork W2361445215 @default.
- W2365237761 hasRelatedWork W2362614580 @default.
- W2365237761 hasRelatedWork W2364867460 @default.
- W2365237761 hasRelatedWork W2371796747 @default.
- W2365237761 hasRelatedWork W2372674295 @default.
- W2365237761 hasRelatedWork W2373731443 @default.
- W2365237761 hasRelatedWork W2376524547 @default.
- W2365237761 hasRelatedWork W2376981082 @default.
- W2365237761 hasRelatedWork W2377688154 @default.
- W2365237761 hasRelatedWork W2378458881 @default.
- W2365237761 hasRelatedWork W2378886867 @default.
- W2365237761 hasRelatedWork W2380786228 @default.
- W2365237761 hasRelatedWork W2383862196 @default.
- W2365237761 hasRelatedWork W2385472976 @default.
- W2365237761 hasRelatedWork W2386644436 @default.
- W2365237761 hasRelatedWork W2387616141 @default.
- W2365237761 isParatext "false" @default.
- W2365237761 isRetracted "false" @default.
- W2365237761 magId "2365237761" @default.
- W2365237761 workType "article" @default.