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- W2365247559 abstract "[Objective]To detect the expression of IL-21 receptor(IL-21R)in peripheral blood mononuclear cells of patients with rheumatoid arthritis(RA),and to explore the immunopathogenesis in the process of the development of RA.[Methods]Peripheral blood of 26 patients with RA and 18 healthy controls were collected to separate the single lymphocyte. The expression of IL-21R in peripheral blood CD4+,CD8+ T cells,B cells and NK cells was detected by flow cytometry.[Results]Expression of IL-21R was significantly increased in peripheral blood CD4+,CD8+ T cells,B cells and NK cells of RA patients when compared with that in controls(P﹤0.05). The expression of IL-21R was significantly decreased in RA patients after controlling the symptom of RA(P﹤0.05).[Conclusion]The expression of IL-21R was significantly increased in peripheral blood mononuclear cells of RA patients,which indicated that IL-21R may play a pathogenic role in the pathological process of RA. The expression of IL-21R may induce the pathological changes of arthrosynovitis and the pathological damage to the Synovial tissue of joint and eneral immunity." @default.
- W2365247559 created "2016-06-24" @default.
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- W2365247559 date "2008-01-01" @default.
- W2365247559 modified "2023-09-23" @default.
- W2365247559 title "EXPRESSION AND SIGNIFICANCE OF IL-21 RECEPTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS" @default.
- W2365247559 hasPublicationYear "2008" @default.
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