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- W2365255180 abstract "Objective To study the feasibility of fibrin sealant as a carrier of staphylococcus aureus injection for repairing bone defects.MethodsTwo 5 mm-diameter bone defects were manufactured symmetrically on both sides of the cranial bone in 30 Wistar rats.Then the rats were divided into experimental group,control group and blank group.Rats were implanted with complex of fibrin sealant and staphylococcus aureus injection in bone defect in experimental group,with fibrin sealant in control group,while nothing was implanted in blank group.After operation for 4 and 6 weeks,general observation,X-ray film and histological examination were performed,and osteotylus ashes weight and wet weight were determined.ResultsAfter operation for 4 and 6 weeks,X-ray revealed that percentage of new bone forming area in experimental group was higher than in control group and blank group,and there was statistically significant difference between three groups(P0.01).After 6 weeks,histological examination revealed that fibrin sealant had been completely absorbed in experimental group and bone defect completely healed.But in control group,fibrin sealant had been completely degraded and there were a large number of new bone at the edge of defect.A small amount of new bone could be seen at the edge of defect in blank group and other parts of defect had been covered by the dense fibrous connective tissue. The ratio of wet weight and ash weight of osteotylus in experimental group was lower than in control group and blank group,and there was significant difference between three groups(P0.01).ConclusionFibrin sealant as a carrier of staphy1ococcus aureus injection for repairing bone is feasible and can reduce the flaws of local injection of staphylococcus aureus injection and improve its drug efficiency." @default.
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- W2365255180 date "2008-01-01" @default.
- W2365255180 modified "2023-09-23" @default.
- W2365255180 title "Staphylococcus aureus injection with fibrin sealant as a carrier for repairing skull defects in rats" @default.
- W2365255180 hasPublicationYear "2008" @default.
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