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- W2365260959 abstract "Objective:To analyze the dynamic changes of CC,IL-8/CXCL8 chemokine in the serum drew from skin graft rabbits which treated with rhIL-10,and to explore the mechanism of rhIL-10 resisting the immune rejection.Methods:The recipient rabbits were randomly divided into six groups: ①:rhIL-10 5 μg/(kg·d);②:rhIL-10 10 μg/(kg·d);③:CsA 5 mg/(kg·d);④:CsA 10 mg/(kg·d);⑤:rhIL-10 5 μg/(kg·d) and CsA 5 mg/(kg·d);⑥:NS 1 ml/d.Giving the medicine 1 day preoperation and use consecutively 10 days by intramuscular injection.Dynamic serum levels of CC,IL-8/CXCL8 chemokines were analyzed by ELISA method 1 d preoperation and 1,4,7,14,21,28 d postoperation.Results:(1)IL-8 serum level in all groups were increased after skin graft,and it in saline control group was significantly higher than in any other groups on postoperative days(PODs)4,7(P0.05).(2) MCP-1 serum level in all groups were increased after skin graft,and it in saline control group was significantly higher than in any other groups on POD1 and 4(P0.05),as well as higher than in ① and ⑤groups on POD7(P0.05).Besides,it in CsA groups were significantly higher than in combination group on POD7 and 14(P0.05).(3) MIP-1α serum level in all groups were increased after skin graft,and it in saline control group was significantly higher than in group ①,③ and ⑤ on POD4,as well as significantly higher than in any other groups on POD7(P0.05).(4) MIP-1β serum level in all groups were increased after skin graft.Conclusion:The expression of CC,IL-8/CXCL-8 chemokines in all groups have been up-regulated after skin allograft hinted that they play important roles in the process of acute rejection.There is a close correlation of serum CC,IL-8/CXCL8 chemokine level with acute allograft rejection,suggesting that they could be regarded as valuable signals of acute allograft rejection." @default.
- W2365260959 created "2016-06-24" @default.
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- W2365260959 date "2011-01-01" @default.
- W2365260959 modified "2023-09-25" @default.
- W2365260959 title "The changes of CC,IL-8/CXCL8 chemokine in the reaction of rhIL-10 resisting the skin graft" @default.
- W2365260959 hasPublicationYear "2011" @default.
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