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- W2365280360 abstract "Objective To investigate the changes of genome chromosomal and the relationship between its related factors and prognosis in gastrointestinal stromal tumors(GISTs),and to provide a reliable evidence for prognosis. Methods Comparative genomic hybridization(CGH)and EnVision immunohistochemical method were used to detect alteration of all genome chromosome and expression of related factors nm23,Cmyc,CerbB-2 and E2F1 in 20 cases of GISTs. Results The loss was much more than the amplification in GISTs,and the loss of 14q,22q and the amplification of 17q,8q were not related to invasion risk of tumor(P0.05).The loss of 1p,15q,13q and the amplification of 5p,20q increased more in high-grade than that in low-grade of GISTs(P0.05),and they were related to recurrence,metastasis and death of GISTs.The positive expression rates of Cmyc and E2F1 were 75% and 65%,respectively.Cmyc and E2F1 were positive in all PD cases of GISTs,and were related to the malignant degree of GISTs(P0.05).The positive expression rate of nm23 was 70%,and was not related to the malignant degree of GISTs(P0.05).CerbB-2 was not detected in 20 cases. Conclusion There are some loss and amplification in GISTs,especially the loss of 14q and 22q.Cmyc,E2F1 protein may be the targets of 8q,20q gene amplification respectively,and they would be the factors of prognosis mala of GISTs." @default.
- W2365280360 created "2016-06-24" @default.
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- W2365280360 date "2008-01-01" @default.
- W2365280360 modified "2023-09-23" @default.
- W2365280360 title "Changes of chromosome and expression of prognosis-related factors in gastrointestinal stromal tumors" @default.
- W2365280360 hasPublicationYear "2008" @default.
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