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- W2365309306 abstract "Objective: To observe the influence of compound phenytoin sodium gel(CPSG) for experimental animals on restoration of the wound's surface and bacterial infection.Method: The incised wound model of mice was established,CPSG(4.25,4.55 g.kg-1) was external applied for 12 days and the wound contraction rate were observed after treatment for 3,6,8,10,12 days.Rats incised wound model accompanied by staphylococcus aureus were replicated,CPSG(1.70,1.82 g.kg-1) was external applied for 12 d,and the wound recovery rate were detected after treatment for 3,6,8,10,12 days.The histopathological changes of wound healing tissue were examined.Result: Compared with the wound contraction rate of gel group(16.77 ± 4.79) %,(29.95 ± 5.63) %,(50.69 ± 4.19) %,(67.47 ± 5.13) %,(82.48 ± 4.40) %,those in low and high doses of CPSG were(20.16 ± 5.78) %,(40.02 ± 9.79) %,(71.04 ± 7.27) %,(96.14 ± 2.53) %,(99.44 ±1.30) %;(28.50 ± 4.77) %,(55.66 ± 8.39) %,(79.67 ± 5.11) %,(96.14 ± 2.53) %,(100.00 ±0.00) % respectively(P 0.05,P 0.01,P 0.01,P 0.01.P 0.01,P 0.01,P 0.01,P 0.01,P 0.01) after treatment for 3,6,8,10,12 days in mice.The wound recovery rate of the low and high dose of CPSG were(29.45 ± 5.11) %,(50.17 ± 4.92) %,(72.48 ± 5.05) %,(87.44 ± 4.11) %,(96.66 ±3.75) %;(33.71 ± 3.43) %,(58.67 ± 5.59) %,(81.86 ± 4.15) %,(95.92 ± 2.39) %,(100.00 ±0.00) % higher than(20.71 ± 3.58) %,(40.42 ± 3.89) %,(58.53 ± 6.21) %,(74.71 ± 9.23) %,(86.47 ± 7.15) % of gel group(all P 0.01) in the treatment of 3,6,8,10,12 days.Conclusion: CPSG could promote the restoration of the wound's surface in the animals with experimental trauma and bacterial infection." @default.
- W2365309306 created "2016-06-24" @default.
- W2365309306 creator A5026782331 @default.
- W2365309306 date "2013-01-01" @default.
- W2365309306 modified "2023-09-24" @default.
- W2365309306 title "Effect of Compound Phenytoin Sodium Gel on Restoration of the Wound`s Surface and Bacterial Infection" @default.
- W2365309306 hasPublicationYear "2013" @default.
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