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- W2365331085 abstract "Objective: To synthesis 4'-N,N-Bis-substituted(aminomethyl) benzoate ether derivatives of scutellarein with improved anti-oxidative activity,and investigation of their protection against nerve cells oxidative damage.Method: Scutellarein 2-bromoethyl ether(4) was synthesized in the presence of 1,8-diazabicyclo[5.4.0] undec-7-ene(DBU) with scutellarein and 2-bromoethanol as starting materials.N-substituted(aminomethyl) benzoic acids(5a-c) were converted to benzoic chloride(6a-c) by using oxalyl chloride,then the latter coupled with 4 in the presence of 4 MS to obtained compounds(7a-f),then diphenyl ketal protecting group of the above compounds was removed by using acetic acid chloride / methanol system to obtain target compounds(8a-f),prodrugs were tested for their cytotoxicity and antioxidant activity in PC12 cells by MTT and LDH leakage rate assay.Result: The structure of synthesized compounds 8a-f was confirmed by the methods of1H-NMR,ESIMS.The results indicated that compound 8e and 8f have more potent anti-oxidative activity than positive control Vitamin E.Conclusion: The synthetic method we used has preferable practicality and can be used in synthesizing scutellarein 4'-N,N-bissubstituted(aminomethyl) benzoate ether derivatives,bioactivity evaluation results suggested that the kind of prodrugs are worthy of further investigation to discover new anti-oxidative agents." @default.
- W2365331085 created "2016-06-24" @default.
- W2365331085 creator A5036503802 @default.
- W2365331085 date "2013-01-01" @default.
- W2365331085 modified "2023-09-25" @default.
- W2365331085 title "Synthesis and Protection Against PC12 Cell Damage of Scutellarein Derivatives Induced by H_2O_2" @default.
- W2365331085 hasPublicationYear "2013" @default.
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