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- W2365349105 abstract "Objective To study the effects of liver cirrhosis on the level of homocysteine(HCY) in plasma and gene expression of proliferating cell nuclear antigen(PCNA) in aortia.Methods CCl4 was used to induce liver cirrhosis in rats.The level of plasma HCY was measured using enzyme-immunoassay.The mRNA levels of cystathione-synthase and PCNA were detected by RT-PCR.Results The level of plasma HCY in rats with hepatic cirrhosis was significantly higher than that of control.A correlation analysis revealed that the HCY level was significantly correlated to the levels of type III procollagen and hyaluronic acid.Both the mRNA level and enzyme activity of cystathione-synthase in rats with hepatic cirrhosis markedly decreased.The mRNA level of PCNA significantly increased,compared with that of control.Conclusions Liver cirrhosis leads to an increase in the level of plasma HCY,due to insult in HCY metabolism.Liver cirrhosis may increase the rate of atherosclerosis." @default.
- W2365349105 created "2016-06-24" @default.
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- W2365349105 date "2008-01-01" @default.
- W2365349105 modified "2023-09-26" @default.
- W2365349105 title "Rising of Homocysteine Level in Plasma and Upregulating of Expression of PCNA in Rats with Liver Cirrhosis induced by Carbon Tetrachloride" @default.
- W2365349105 hasPublicationYear "2008" @default.
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