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- W2365349961 abstract "Objective:To investigate the effects of azithromycin on prothrombin time(PT) and International Normalized Ratio(INR) as pharmacodynamics index and plasma concentration of warfarin as pharmacokinetics index in rats treated orally with warfarin.Methods:16 healthy SD rats were randomly divi-ded into two groups:group A(n=8),given warfarin alone and group B(n=8),given warfarin in combination with azithromycin.Rats in both groups were given with warfarin(0.2 mg ·kg-1,po,qd) for 6 d.On day 6,rats in group B were administered simultaneously with azithromycin(80 mg ·kg-1,ip) and timing started.Blood in rats in both groups was collected respectively at 0.25,0.5,1.5,2.5,3.5,5,7,10,13 h.PT and INR of rats were measured using thromboplastin reagent.The plasma concentration of warfarin was determined by HPLC.Results:Compared with group A,PT value of rats started to increase significantly at 5 h(P0.05),the maximum INR value reached 7.5 and Tmax of warfarin was significantly prolonged(P0.01) in group B.However,other pharmacokinetic parameters showed no significant difference between both groups.The INR-C curves in two groups showed counter-clock-wise hysteresis loop,which was more significant in group B.Conclusion:The combination of warfarin with azithromycin could induce pharmacodynamic and pharmacokinetic interactions to enhance warfarin′s anticoagulant activity resulting in the increased hemorrhage risk.So the INR of the patient co-administered with both the drugs should be closely monitored to avoid serious adverse reaction." @default.
- W2365349961 created "2016-06-24" @default.
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- W2365349961 date "2010-01-01" @default.
- W2365349961 modified "2023-09-23" @default.
- W2365349961 title "Effects of Azithromycin on the Pharmacokinetics and Pharmacodynamics of Oral Warfarin in Rats" @default.
- W2365349961 hasPublicationYear "2010" @default.
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