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- W2365356763 abstract "Objective:To investigate the action mechanism of Fuzheng Huayu Recipe(FZHY) against renal interstitial fibrosis via regulating the activity of matrix metalloproteinases.Methods:Male SD Rats were randomly divided to normal,model and FZHY treatment group.Renal interstitial fibrosis model was induced by oral administration of HgCl2 for 8 weeks,while the rats in the treatment group received FZHY.Blood serum creatinine(Cr) and blood urea nitrogen(Bun) content were determined with kits;HydroxyProline(Hyp) content of kidney was determined with Jamall's method.Kidney infalammation and collagens deposition were observed with HE and Masson staining.Expression of MMP-13,MT1-MMP,MMP-2 and TIMP-1/2 were analyzed with Western blot.The activities of renal tissue MMP-2 and MMP-13 were assayed respectively with zymography and SensoLyteTM520 MMP-13 Assay kit.Results:FZHY group decreased kidney Hyp content and improve serum renal function in fibrotic kidneys,as well as alleviated collagen deposition.Also compared with the model group,FZHY group increased the expression and activity of MMP-13,but decreased the expression of MMP-2,MT1-MMP and TIMP-1/2,and MMP-2 activity.Conclusion:FZHY action mechanisms against liver fibrosis were related to down-regulating gelatinase(MMP-2) activity and protecting basement membrane structure,and up-regulating interstitial collagnase(MMP-13) activity through inhibiting TIMP-1 expression." @default.
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- W2365356763 date "2010-01-01" @default.
- W2365356763 modified "2023-09-24" @default.
- W2365356763 title "Effect of Fuzheng Huayu Recipe on activity of matrix metalloproteinases in rats with renal interstitial fibrosis." @default.
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