Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365356987> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2365356987 abstract "Objective To study the relationship between Ephrin-A1 and its receptor with angiogenesis in hepatocellular carcinoma(HCC).Methods Immunohistochemistry staining method(S P methods)and reverse transcription polymerase chain reaction(RT-PCR) were used to determine the protein and mRNA expression of Ephrin-A1 and its receptor EphA1、EphA2 in tumor tissues and their corresponding adjacent liver tissues from 52 HCC patients;then,analyse of the relationship between Ephrin-A1 and clinicopathologyfactor and microvessel density(MVD) in HCC was made.Results The protein expression rate of Ephrin-A1 and EphA1,EphA2 in HCC was 59.6%(31/52),53.8%(28/52)and 17.3%(9/52),respectively,but in the paired liver tissues adjacent to HCC the expression rate was 23.1%(12/52),and respectively.The protein expression rate of Ephrin-A1 and EphA1 was significantly higher than that in the paired liver tissues adjacent to HCC(P0.05),The protein expression rate of EphA2 was not significant in HCC compared to the paired liver tissues adjacent to HCC(P0.05).The mRNA express rate of Ephrin-A1 and EphA1 in HCC [67.3%(35/52) and 73.7%(38/52)] were prominently higher than those in the paired liver tissues adjacent to HCC [42.3%(22/52) and 48.1%(25/52)](P0.05),The mRNA express rate of EphA2 was no significant in HCC compare to the paired liver tissues adjacent to HCC(P0.05).The higher expression of Ephrin-A1 was correlated with the AFP level and thrombus in the portal vein(P0.05) in patients with HCC.Spearman′s rank correlation analysis indicatied the expression of Ephrin-A1 was correlated with EphA1(r=0.671,P0.01),but was not correlated with EphA2 in HCC;and the expression of Ephrin-A1 was correlated with MVD in HCC(r=0.826,P0.01).Conclusions Ephrin-A1 can be combination with its receptor EphA1 but not with EphA2 in HCC,and can improve angiogenesis of HCC,then enhanced its growth,invasiveness and metastasis.Ephrin-A1 and EphA1 can become the new targets for the antiangiogenesis treatment of HCC." @default.
- W2365356987 created "2016-06-24" @default.
- W2365356987 creator A5058913302 @default.
- W2365356987 date "2007-01-01" @default.
- W2365356987 modified "2023-09-25" @default.
- W2365356987 title "The relationship between the expression of Ephrin-A1 and its receptor to angiogenesis in HCC" @default.
- W2365356987 hasPublicationYear "2007" @default.
- W2365356987 type Work @default.
- W2365356987 sameAs 2365356987 @default.
- W2365356987 citedByCount "0" @default.
- W2365356987 crossrefType "journal-article" @default.
- W2365356987 hasAuthorship W2365356987A5058913302 @default.
- W2365356987 hasConcept C101544691 @default.
- W2365356987 hasConcept C104317684 @default.
- W2365356987 hasConcept C105580179 @default.
- W2365356987 hasConcept C126322002 @default.
- W2365356987 hasConcept C142724271 @default.
- W2365356987 hasConcept C150582083 @default.
- W2365356987 hasConcept C170286479 @default.
- W2365356987 hasConcept C170493617 @default.
- W2365356987 hasConcept C19331615 @default.
- W2365356987 hasConcept C204232928 @default.
- W2365356987 hasConcept C2776436680 @default.
- W2365356987 hasConcept C2778019345 @default.
- W2365356987 hasConcept C2780394083 @default.
- W2365356987 hasConcept C4692481 @default.
- W2365356987 hasConcept C502942594 @default.
- W2365356987 hasConcept C55493867 @default.
- W2365356987 hasConcept C71924100 @default.
- W2365356987 hasConcept C86803240 @default.
- W2365356987 hasConceptScore W2365356987C101544691 @default.
- W2365356987 hasConceptScore W2365356987C104317684 @default.
- W2365356987 hasConceptScore W2365356987C105580179 @default.
- W2365356987 hasConceptScore W2365356987C126322002 @default.
- W2365356987 hasConceptScore W2365356987C142724271 @default.
- W2365356987 hasConceptScore W2365356987C150582083 @default.
- W2365356987 hasConceptScore W2365356987C170286479 @default.
- W2365356987 hasConceptScore W2365356987C170493617 @default.
- W2365356987 hasConceptScore W2365356987C19331615 @default.
- W2365356987 hasConceptScore W2365356987C204232928 @default.
- W2365356987 hasConceptScore W2365356987C2776436680 @default.
- W2365356987 hasConceptScore W2365356987C2778019345 @default.
- W2365356987 hasConceptScore W2365356987C2780394083 @default.
- W2365356987 hasConceptScore W2365356987C4692481 @default.
- W2365356987 hasConceptScore W2365356987C502942594 @default.
- W2365356987 hasConceptScore W2365356987C55493867 @default.
- W2365356987 hasConceptScore W2365356987C71924100 @default.
- W2365356987 hasConceptScore W2365356987C86803240 @default.
- W2365356987 hasLocation W23653569871 @default.
- W2365356987 hasOpenAccess W2365356987 @default.
- W2365356987 hasPrimaryLocation W23653569871 @default.
- W2365356987 hasRelatedWork W2306865096 @default.
- W2365356987 hasRelatedWork W2352155529 @default.
- W2365356987 hasRelatedWork W2355989395 @default.
- W2365356987 hasRelatedWork W2358822463 @default.
- W2365356987 hasRelatedWork W2361664764 @default.
- W2365356987 hasRelatedWork W2362096790 @default.
- W2365356987 hasRelatedWork W2362240044 @default.
- W2365356987 hasRelatedWork W2363515967 @default.
- W2365356987 hasRelatedWork W2364769022 @default.
- W2365356987 hasRelatedWork W2366135006 @default.
- W2365356987 hasRelatedWork W2379281224 @default.
- W2365356987 hasRelatedWork W2382706027 @default.
- W2365356987 hasRelatedWork W2382757488 @default.
- W2365356987 hasRelatedWork W2383235593 @default.
- W2365356987 hasRelatedWork W2387835089 @default.
- W2365356987 hasRelatedWork W2389342231 @default.
- W2365356987 hasRelatedWork W2390255641 @default.
- W2365356987 hasRelatedWork W2392605871 @default.
- W2365356987 hasRelatedWork W2410888760 @default.
- W2365356987 hasRelatedWork W3030187227 @default.
- W2365356987 isParatext "false" @default.
- W2365356987 isRetracted "false" @default.
- W2365356987 magId "2365356987" @default.
- W2365356987 workType "article" @default.