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- W2365362711 abstract "AIM:To study the antitumor activities and its mechanism of matrine (Mat) in vivo. METHODS:Lewis lung carcinoma (LLC) cells was transplanted into the subcutaneous space on the armpit of each C57BL mouse. Mice were randomized into tumor model,cyclophosphamide (CTX),Mat (80,40 and 20 mg/kg) alone and combination with CTX groups. After 21 d intragastric administration,the mean weight of the subcutaneous tumors was examined,average inhibition rate was analyzed,and then the average tumor growth curve was drawn. The body and viscera weight was examined. Radioimmunoassay (RIA) was used to determine the serum concentration of epidermal growth factor (EGF) in C57BL mice. RESULTS:The administration of Mat alone had no effect on LLC growth (P0.05). The tumor control rate of Mat (80 mg/kg) combined with CTX group was 42.69%; compared with CTX group (56.78%),it increased significantly (P0.01). In the group treated by Mat (80,20 mg/kg) and CTX,concentration of EGF in serum was (0.14±0.03) mg/L and (0.11±0.02) mg/L respectively,and it decreased significantly as compared with tumor model and CTX group (P0.01). CONCLUSION:Mat can enhance the inhibition of CTX to the growth of mouse LLC,and its mechanism may be related with its action of decreasing the serum concentration of EGF." @default.
- W2365362711 created "2016-06-24" @default.
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- W2365362711 date "2008-01-01" @default.
- W2365362711 modified "2023-10-17" @default.
- W2365362711 title "Enhanced antitumor activity of cyclophosphamide in combination with matrine on Lewis lung carcinoma in mice" @default.
- W2365362711 hasPublicationYear "2008" @default.
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