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- W2365366372 abstract "Objective To investigate the effect of TNF-α on vascular cell adhesion molecule-1(VCAM-1) expression and secretion in human aortic endothelial cell(HAEC),and the probable intracellular signaling pathway.Methods HAECs were incubated with 10 ng/mlTNF-α for various periods,VCAM-1 protein expression,phosphorylation of ERK1/2 and JNK were detected by Western blot.Soluble VCAM-1(sVCAM-1) in the conditioned media was detected by ELISA.HAECs were pre-incubated with PD98059(MEK-ERK1/2 inhibitor) or SP600125(JNK inhibitor) for 1 h,subsequently with TNF-α for 4 h,expression and secretion of VCAM-1 were assessed.Results TNF-α induced expression of VCAM-1 protein in a time-dependent manner,with a peak at 4 h(5.80±0.44 folds vs control group).The level of sVCAM-1 in the conditioned media was parallel to the protein expression.SP600125,but not PD98059,reduced TNF-α-induced expression of VCAM-1.Conclusions TNF-α-induced expression of VCAM-1 in HAECs is mediated by JNK signaling at least partly." @default.
- W2365366372 created "2016-06-24" @default.
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- W2365366372 date "2009-01-01" @default.
- W2365366372 modified "2023-09-25" @default.
- W2365366372 title "JNK signaling-mediated up-regulation of VCAM-1 by TNF-α in human aortic endothelial cells" @default.
- W2365366372 hasPublicationYear "2009" @default.
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