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- W2365377557 abstract "Objective:To study the effects of γ-aminobutyric acid on morphine withdrawal symptoms in rats and its possible mechanism. Methods:Morphine-dependent rats were induced by subcutaneous injection of morphine in gradually increasing doses. GABA 10 μl (500 μg·10 μl -1 )or saline (0.9%) were administered intracerebroventricularly (icv) to the morphine dependent rats 30 min before peak incidence of morphine withdrawal symptoms displayed and then to observe its changes. Nitric oxide synthase(NOS)activity and nitric oxide(NO)output were assessed with spectrophotometric analysis. Results:GABA can significantly attenuate withdrawal behaviors such as grooming,wet dog shakes, writhing,teeth gnashing and cunnilingus movements,and can effectively inhibit autonomic hyperactivity. Levels of NOS activity,NO output in serum,brain tissue around NAc were increased significantly during the period of morphine withdrawal compared with the saline group(P0.05), while GABA(icv)could inhibit the enhancement of NOS activity, NO output in morphine abstinence session(P0.05). Conclusion: GABA can decrease the incidence of morphine withdrawal behavior. GABA action of antagonizing drug-dependence may be correlated with the opioid receptors,which can reduce the expression of NO in CNS." @default.
- W2365377557 created "2016-06-24" @default.
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- W2365377557 date "2006-01-01" @default.
- W2365377557 modified "2023-09-24" @default.
- W2365377557 title "EFFECTS OF Γ-AMINOBUTYRIC ACID ON MORPHINE WITHDRAWAL SYMPTOMS IN RATS AND ITS POSSIBLE MECHANISM" @default.
- W2365377557 hasPublicationYear "2006" @default.
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