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- W2365378092 abstract "Objective To prepare nanostructured lipid carriers containing meloxicam(MX-NLC)and lyophilized NLC,and evaluate the physic-chemical characteristics of MX-NLC before and after lyophilyzation.Methods MX-NLC was prepared by a high pressure homogenization method,and then the lyophilized NLC was developed to improve the stability.With the criteria of content,particle diameter,and encapsulation efficiency,the physicochemical characteristics of MX-NLC before and after lyophilyzation were evaluated.Results The mean encapsulation efficiency of three batches were 73.6% and 72.5% before and after lyophilyzation while he mean particle size was 137 nm and 154 nm.In vitro release study,MX-NLC showed a sustained release profile.Conclusions The nanostructured lipid carriers loaded with meloxicam can be prepared by high pressure homogenization method and lyophilyzation.The prepared MX-NLC with the particle size between 100 nm to 200 nm shows a sustained release profile,from which we can infer that the preparation may realize passive targeting by intravenous injection." @default.
- W2365378092 created "2016-06-24" @default.
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- W2365378092 date "2013-01-01" @default.
- W2365378092 modified "2023-09-23" @default.
- W2365378092 title "Preparation and characterization of meloxicam-loaded nanostructured lipid carriers" @default.
- W2365378092 hasPublicationYear "2013" @default.
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