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- W2365381791 abstract "Aim To investigate the effects and mecha of ganoderma lucidum polysaccharides and metforminon pathological changes of thoracic aorta in diabetic rats and the mechanisms. Methods SD rats were fed with high fat diet for 4 weeks and injected with streptozotocin( 30 mg · kg- 1) to replicate type 2 diabetic model. The diabetic rats were randomly into diabetes group,ganoderma lucidum polysaccharides group( 600mg·kg- 1),metformin group( 600 mg·kg- 1),combination group( ganoderma lucidum polysaccharides 300mg· kg- 1+ metformin 300 mg · kg- 1) and normal control group. After 12 weeks' treatment,the levels of fasting serum glucose,the activity of catalase( CAT),glutathione peroxidase( GSH-Px),total cholesterol( TC) and triglyceride( TG) in serum were detected.Pathological changes of thoracic aorta were observed by HE staining. Immunohistochemy and Western blot were used to detect thoracic aorta VEGF protein expression.Results Combination group could lower fasting serumglucose and blood fat significantly,meanwhile the activity of CAT and GSH-Px in serum was improved. The expression of VEGF in thoracic aorta was repressed.The result of HE staining suggested that the lipid deposits in aortic endothelium in combination group were less than those in the model group. Conclusions Ganoderma lucidum polysaccharides combined with metformin has an obvious prevention on pathological changes of thoracic aorta in diabetic rats. The possible mechanism may be related to repressing oxidative stress of thoracic aorta,regulating the dyslipidemia,and the down regulation of the expression of VEGF in thoracic aorta." @default.
- W2365381791 created "2016-06-24" @default.
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- W2365381791 date "2014-01-01" @default.
- W2365381791 modified "2023-09-25" @default.
- W2365381791 title "Effect of combination of ganoderma lucidum polysaccharide and metformin on aortic lesions and expression of VEGF in type 2 diabetic rats" @default.
- W2365381791 hasPublicationYear "2014" @default.
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