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- W2365398465 abstract "OBJECTIVE To investigate the expression of breast cancer stem cells surface marker CD44+CD24-in a breast cancer cell line BICR H1,and to investigate the anti-cancer drug sensitivity of BICR H1.METHODS The expression of CD44+CD24-on the surface of BICR H1 was determined by flow cytometry and fluorescence confocal microscopy,and the sensitivity of BICR H1 on various types of anti-cancer drugs was determined by MTT method.RESULTS The ratio of the expression of CD44+CD24-on the surface of BICR H1 was over 95%.In 5-fluorouracil and cisplatin treatment group,there was no inhibition effect on cell growth at 48 h,and the IC50 values were both above 50 μmol·L-1 at 72 h;In adriamycin treatment group,the IC50 values were 3.4 and 1.3 μmol·L-1 at 48 and 72 h respectively;In mitoxantrone treatment group,the IC50 values were 4.7 and 2.6 μmol·L-1 at 48 and 72 h respectively;In bortezomib treatment group,the IC50 values were both below 10 nmol·L-1 at 48 and 72 h.CONCLUSION BICR H1 is a CD44+CD24-highly-expressed breast cancer cell,and the cells were resistant to animetabolites 5-fluorouracil and DNA alkelating agent cisplatin,middle-sensitive to anthracyclines adriamycin and mitoxantrone,and highly-sensitive to protease inhibitor bortezomib.These results indicate that anthracyclines could be used for breast cancer stem cells targeting therapy,and bortezomib is a very potential drug in this filed." @default.
- W2365398465 created "2016-06-24" @default.
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- W2365398465 date "2010-01-01" @default.
- W2365398465 modified "2023-09-23" @default.
- W2365398465 title "Sensitivity of a CD44~+CD24~- Highly-Expressed Breast Cancer Cell Line BICR H1 on Various Types of Anti-Cancer Drugs" @default.
- W2365398465 hasPublicationYear "2010" @default.
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