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- W2365402543 abstract "Objective:To observe the effects of Zhongfei Mixture(ZM) on the expression of survivin and caspase-3 in tumor tissues from the mice bearing Lewis lung carcinoma. Methods:Fifty C57BL/6 mice bearing Lewis lung carcinoma were divided into 5 groups:the saline control group,the low,mid and high-dose groups of ZM and Cyclophosphamide(CTX) group. Tumor tissues were isolated after 12 days followed by the expression detection of survivin and caspase-3 in tumor tissues by EnVision two-step immuno-histochemistry staining. Results:ZM could down-regulate the expression level of survivin and up-regulating caspase-3 in tumor tissues from the mice bearing Lewis lung carcinoma. Compared with saline control group,the effect of the mid-dose group was the most prominent and showed significantly different in statistics(P0.01). Conclusion:ZM could inhibit proliferation and induce apoptosis in tumor cells from the mice bearing Lewis lung carcinoma. The possible mechanism is associated with down-regulating the expression level of survivin and up-regulating caspase-3 in tumor tissues respectively." @default.
- W2365402543 created "2016-06-24" @default.
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- W2365402543 date "2010-01-01" @default.
- W2365402543 modified "2023-09-23" @default.
- W2365402543 title "The Effects of Zhongfei Mixture on the Expression of Survivin and Caspase-3 in Tumor Tissues from the Mice Bearing Lewis Lung Carcinoma" @default.
- W2365402543 hasPublicationYear "2010" @default.
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