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- W2365417425 abstract "Objective To evaluate the efficacy and safety of 0.03% topical Tacrolimus ointment combine with 308nm excimer laser in treatment of psoriasis vulgaris.Methods Fourty five patients of psoriasis vulgaris were divided into two groups randomly.21 patients in the treatment group were treated twice daily with 0.03%Tacrolimus ointment combined with 308nm excimer laser twice weekly,24 patients in the control group were only treated with 0.03%Tacrolimus ointment.Patients were followed up in each of the two weeks.Results The total effective rate was 42.86%,61.90%,85.71% in the treatment group after 2,4,6 weeks respectively,which were higher than that in the control group(16.67%,29.16% and 62.50%)and showed significant difference among three groups(P0.05).Also,the efficacy increased and PASI scores decreased with the increasing of the treatment time in the treatment group.PASI scores 2.32±2.62 at 6 weeks,were significantly lower than that before treatment(11.38±2.97),2 weeks(4.59±4.19),4 weeks(6.86±4.50)and the control group during the same periods(4.75±1.26,11.70±2.51,9.46±2.23 and 6.58±1.38).There were significant differences among three different treatment time(P0.05).However,there were no statistical significance in the effective rates of head,intertriginous areas,back,abdominal region and extremities.No serious adverse events were observed.Both of treatment time and dose.of head and intertriginous areas were lower than other places in the treatment group.Conclusion The combination of 0.03% topical Tacrolimus ointment and 308nm excimer laser represented an effective and well-tolerated therapy for psoriasis vulgaris." @default.
- W2365417425 created "2016-06-24" @default.
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- W2365417425 date "2012-01-01" @default.
- W2365417425 modified "2023-09-26" @default.
- W2365417425 title "Clinical Efficacy of 0.03% Topical Tacrolimus Ointment Combined with 308nm Excimer Laser in Treatment of Psoriasis Vulgaris" @default.
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