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- W2365420737 abstract "Objective To investigate the association of-1131T/C and 553G/T polymorphisms and their haplotypes in apolipoprotein A5(apo A5) gene with carotid atherosclerosis in the patients with cerebral infarction.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was performed to analyze the genotypes and calculated the frequencies of genotypes and alleles for the two genentic variants in 272 patients with cerebral infarction.Moreover,applied SNP Alyze V6.0 software to construct and analyze haplotypes of two polymorphic sites.The common carotid artery(CCA) and internal carotid artery(ICA) intima media thickness(IMT) were used to evaluate the degree of carotid atherosclerosis.Results CCA and ICA IMT levels of 272 patients with cerebral infarction were measured to evaluate the extent of carotid artherosclerosis.CCA IMT and ICA IMT for-1131CC genotype subjects and-1131TT+TC genotypes carriers showed no significant change among them(P0.05).Moreover,for 553G/T polymorphism,the levels of CCA IMT were(1.09±0.18) mm and(1.17±0.18) mm among cerebral infarction patients with TT+GT and GG genotypes(P0.05),but the difference had no statistical significance at the ICA IMT level(P0.05).Moreover,the major haplotype pairs including TG-TG,TG-CG,TG-CT,CG-CG,had significant differences at the levels of ICA IMT(P0.05).Conclusions-1131T/C and 553G/T polymorphisms of apo A5 gene and their haplotype pairs should be in cooperation on the progression of carotid atherosclerosis in patients with cerebral infarction." @default.
- W2365420737 created "2016-06-24" @default.
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- W2365420737 date "2008-01-01" @default.
- W2365420737 modified "2023-09-28" @default.
- W2365420737 title "The associated study of apolipoprotein A5 gene polymorphisms with carotid atherosclerosis in patients with cerebral infarction" @default.
- W2365420737 hasPublicationYear "2008" @default.
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