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- W2365431728 abstract "Aim To investigate the mechanism of apoptosis on human esophageal cancer Eca-109 cell carcinoma xenograft in nude mice induced by paeonol(Pae)by detecting changes of expressions of COX-2,Bcl-2 and Survivin.Methods Human esophageal carcinoma Eca-109 cells were cultured in vitro. After the nude mice model of the subcutaneous transplanting tumor was established by human esophageal cancer Eca-109,the nude mice were randomly divided into six groups:various dosages of Pae treated groups(25,50,100,200 mg·kg-1),cisplatin(CDDP)positive control group(5 mg·kg-1)and model group.After two weeks of treatment,mice were killed and the tumors were taken out to weigh.The tumor inhibitory rate was calculated. Cell apoptosis in situ was examined by a TUNEL assay in the samples of carcinoma. Immunohistochemistry(S-P)was used to examine the expressions of COX-2,Bcl-2 and Survivin.Results The growth of implanted tumor was markedly inhibited in Pae groups(50,100,200 mg·kg-1)and CDDP group(5 mg·kg-1),the inhibitory rate being 23.54%,27.91%,34.46%,58.71% respectively(P0.05 or P0.01).It was found that the apoptotic cells which stained yellow distributed scatterly or diffusely by TUNEL techniques.The apoptosis indexes of Pae groups were (11.02±2.58)%,(19.80±2.77)%,(24.48±4.35)% and(27.13±4.39)% respectively,which were significantly higher than (4.81±0.83)% in control group(P0.05 or P0.01).The expressions of COX-2,Bcl-2 and Survivin in Pae groups were significantly lower than those of the control group detected by immunohistochemistry (P0.05 or P0.01).Conclusion Pae could inhibit the tumor growth and induce apoptosis of human esophageal carcinoma Eca-109 in vivo,the mechanism of which might be related with down-regulation of COX-2,Bcl-2 and Suvivin." @default.
- W2365431728 created "2016-06-24" @default.
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- W2365431728 date "2008-01-01" @default.
- W2365431728 modified "2023-09-28" @default.
- W2365431728 title "Investigation of apoptosis mechanism of Pae on human esophageal cancer Eca-109 cell carcinoma xenograft in nude mice" @default.
- W2365431728 hasPublicationYear "2008" @default.
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