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- W2365433055 abstract "Objective To observe if 70 ku recombinant heat shock protein from Trichinella spiralis(rTs-Hsp70) activates murine bone marrow-derived dendritic cells(BMDCs) in vitro.Methods Murine BMDCs were isolated and cultured in vitro.After five days of culturing,BMDCs were cultured together with rTs-Hsp70 for 24 hours.The cytokines IL-12P70 and TNF-α,which were produced in BMDC culture supernatants stimulated with rTs-Hsp70 in vitro,were detected by ELISA.The levels of CD11c and CD86 were examined with flow cytometry.At the same time,the morphologies of BMDCs were observed.BMDCs cultured with LPS,with denatured rTs-Hsp70,and without stimulation served as controls.Results The level of IL-12P70 or TNF-α in BMDCs stimulated with rTs-Hsp70 differed statistically from BMDCs without stimulation(P0.05).The percentage content of CD86+ double-positive cells in BMDCs stimulated with rTs-Hsp70 was 27.0%.Electron microscopy revealed that BMDCs stimulated with rTs-Hsp70 had a mature morphology and that projections from adjacent cells formed a link between cells.Conclusion rTs-Hsp70 activates DCs by stimulating their maturation,and this finding provides clues about the mechanism of action of rTs-Hsp70 in the immune response to T.spiralis." @default.
- W2365433055 created "2016-06-24" @default.
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- W2365433055 date "2010-01-01" @default.
- W2365433055 modified "2023-09-28" @default.
- W2365433055 title "Trichinella spiralis-derived recombinant heat shock protein activates murine bone marrow-derived dendritic cells" @default.
- W2365433055 hasPublicationYear "2010" @default.
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