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- W2365436044 abstract "Objective: To establish an animal model of degeneration of the intervertebral disc to imitate human pathogenesis.Methods: Twenty adult Japanese white rabbits were randomized into the model group and control group,10 in each.Under anesthesia,rabbits in the model group were operated to destabilize lumbar intervertebral disc and then given extra-mechanical load to promote the injury;and rabbits in the control group were sutured back just after incision.Both groups were fed in the same conditions and every 5 rabbits in each group were sacrificed to perform MRI and pathological examination in 1 and 2 months after surgery.Results: In 2 months after surgery,MRI showed degeneration in the lumbar intervertebral disc and typical pathological changes of degeneration were observed in the model group.No degeneration was observed in the control group.Conclusion: Destabilizing the lumber disc plus mechanical loading can steadily induce degeneration of the intervertebral disc in rabbits.The development of pathological changes in this model is close to the degenerative disc disease in humans." @default.
- W2365436044 created "2016-06-24" @default.
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- W2365436044 date "2011-01-01" @default.
- W2365436044 modified "2023-09-23" @default.
- W2365436044 title "Establishment of Degenerative Lumber Disc Disease Model by Giving Abnormal Mechanical Load and Surgical Destabilization of Intervertebral Disc in Rabbits" @default.
- W2365436044 hasPublicationYear "2011" @default.
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