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- W2365438542 abstract "Objective To observe influence of Shenxiong Injection on the rats' behavioral changes,cerebral infarct volume and hemorheology after focal cerebral ischemia and reperfusion, as well as to explore neuroprotective effects of Shenxiong Injection.Methods Twenty four male rats were randomly divided into four groups,namely:the sham-operated group, control group, Ligustrazin-treated group and Shenxiong Injection-treated group.Rats models of focal cerebral ischemia and reperfusion(I/R) were made by using suture. Zea Longa method was introduced to evaluate behavioral changes and TTC staining was applied to show cerebral infarction.The indexes of hemorheology was sampled at I1hR24h.Result Zea Longa evaluation showed no significant difference among Shenxiong Injection-treated group, Ligustrazin-treated group and control group at both IlhR6h and I1hR24h,only in Shenxiong Injection-treated group,there was significant difference between IlhR6h and I1hR24h (t test,P0.05);Compared with control group,cerebral infarct volume in Shenxiong Injection-treated group and Ligustrazin-treated group decreased significantly(t test,P0.05),but there was no significant difference between Shenxiong Injection-treated group and Ligustrazin-treated group;The blood showed pathologic change of mucosity, thickness and aggregation in the MCAO rats,The indexes of hemorheology was improved significantly in Shenxiong Injection-treated group(t test,P0.01 or P0.05),which was better than the effect of Ligustrazin.Conclusion Shenxiong Injection may have neuroprotective effcts on cerebral ischemia damage induced by focal cerebral ischemia and reperfusion in rats." @default.
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- W2365438542 date "2006-01-01" @default.
- W2365438542 modified "2023-09-25" @default.
- W2365438542 title "Effects of Shenxiong Injection on the Behavioral Changes and Hemorheology after Focal Cerebral Ischemia and Reperfusion in Rats" @default.
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