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- W2365446170 abstract "Objective To study the expression of CD44V6 protein in nasopharyngeal carcinoma(NPC) and its relation to the invasion and metastasis of NPC.Methods By routine immunohistochemical staining,the expressions of CD44V6 protein in 229 NPC and 20 normal samples were studied,and the relationship between positive expression of CD44V6 and NPC invasions or metastases was analyzed.Results In the normal cases the expression of CD44V6 was all negative.And in NPC cases,the positive expression rat of CD44V6 was considerable high,the general positive rat was 83.0%.Furthermore,the strong expression rat was 63.8%.And it was up to 93.3% and 94.4% respectively in the tissues of T 1N 3M 0 and T xN xM 1.But the difference of positive rates was not significant(P0.05) between the up-type and down-type of NPC,or between the cases with and without metastases,including neck lymph node or distant organ metastases.Also the intensity of positive expression of CD44V6 protein was related to neither the stage T(P0.05) nor N(P0.05).Conclusion The expression of CD44V6 protein is negative in the case of free cancer,but high positive in NPC.It suggests that detectable CD44V6 will be in favor of clinical diagnosis of NPC.But there is no relationship between the positive expression and the invasion or regional lymph node metastases of NPC.And it is worthwhile to study the relationship between the CD44V6 and the distant metastasis of NPC." @default.
- W2365446170 created "2016-06-24" @default.
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- W2365446170 date "2000-01-01" @default.
- W2365446170 modified "2023-09-23" @default.
- W2365446170 title "Relationship Between the Expression of CD44V6 and Invasion or Metastasis in NPC" @default.
- W2365446170 hasPublicationYear "2000" @default.
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