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- W2365448002 abstract "Objective To explore the change and mechanisms of β2-adrenoceptor(β2-AR) expression in rabbits' cardiomyocytes with chronical hypoxia.Methods A chronically cyanotic model was surgically created by anatomizing the pulmonary artery branch to the left auricle of heart in rabbits.The isolated rabbit hearts were quickly mounted on Langendorff apparatus,and perfused retrogradely with enzymic method.There were three groups: the control,sham,and chronically cyanotic model group(CCM) in the experiment.The viability of cardiomyocytes was tested.The expressions of β2-AR,caspase-3,p-Akt were assessed by Western blot.Results Five weeks after the surgery,partial pressure of oxygen(PO2) and arterial Oxygen Saturation(SaO2) were decreased significantly detected by arterial blood gas analysis in CCM.The viability of cardiomyocytes was significantly reduced in CCM.CCM diminished the expression of β2-AR and p-Akt,but increased the expression of caspase-3.Conclusion These data suggest that CCM decrease the expression of β2-AR and the possible mechanism may be involved in increased cardiomyocyte apoptosis with phospho-inositide-3 kinase-Akt-dependent(PI3K/Akt) pathway." @default.
- W2365448002 created "2016-06-24" @default.
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- W2365448002 date "2010-01-01" @default.
- W2365448002 modified "2023-09-27" @default.
- W2365448002 title "The Change and Mechanism of β_2-adrenoceptor Expression in Rabbit Cardiomyocytes Under Chronical Hypoxia" @default.
- W2365448002 hasPublicationYear "2010" @default.
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