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- W236546179 abstract "5-Fluorouracil (5-FU) has been the most significant drug in the management of colorectal cancer for the previous 40 yr. Its mechanism of action, toxicity profile, mechanisms of resistance, and clinical utility have been clearly defined through many clinical trials and basic science research efforts (see Chapters 25 and 26). It is established in the key role of systemic therapy in both the metastatic setting as well as the adjuvant setting for colorectal cancer. Likewise, it is used for many other cancers of the gastrointestinal (GI) tract, head and neck region, and breast cancer. For the past 10–15 yr, the focus of research has been on improving the clinical efficacy of 5-FU through biochemical modulation. The addition of such agents as leucovorin have demonstrated improvement in response rates but have only minimally advanced survival outcomes (1–3). Alterations in dose and schedule of 5-FU have likewise resulted in improvement in response rates without large changes in survival outcomes. Most significantly, prolonged infusions of low-dose 5-FU have been found to generate a lower-toxicity profile as well as equal or improved clinical outcomes, including a survival advantage (Table 1) (4). Unfortunately, the administration of intravenous 5-FU chronically is somewhat tedious and burdensome for patients and physicians alike. Logically, the development of an oral 5-FU equivalent would have dramatic implications for the therapy of colon cancer as well as for patient quality of life (5)." @default.
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- W236546179 date "2002-01-01" @default.
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- W236546179 title "Oral Fluoropyrimidines in Colorectal Cancer" @default.
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