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- W2365463216 abstract "The effect of penetration enhancers on the in vitro permeabilityof levonorgestrel(1) through excised mouse skin under various conditions wasevaluated using HPLC-UV.When the saturated solution of 1 in ethanol wasused as donor phase and the skin was pretreated with enhancers for 4h,pro-pylene glycol(PG) and PVP-oleic acid showed significant enhancing ability,whileoleic acid,laurocapram,phthalate had the negative aciton.When the unpretreat-ed skin was employed,the enhancers,such as PG,dissolved in saturated watersolution of 1 showed almost no promoting effect.EVA-matrix patches fabricatedby solvent casting method containing 1 and enhancer were adhered to the mouseskin,the enhancing effect of all enhancers except oleic acid was in good agree-ment with the results of pretreated skin." @default.
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- W2365463216 date "1993-01-01" @default.
- W2365463216 modified "2023-09-25" @default.
- W2365463216 title "EFFECT OF PENETRATION ENHANCERS ON IN VITRO PERMEABILITY OF LEVONORGESTREL IN POSTCOITAL TRANSDERMAL CONTRACEPTIVE PATCH THROUGH EXCISED MOUSE SKIN" @default.
- W2365463216 hasPublicationYear "1993" @default.
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