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- W2365488034 abstract "Aim: To investigate the expression of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) in esophageal and cardiac carcinoma tissue. Methods: The expression of P-pg and MRP was analyzed by immunohistochemistry in 50 cases of esophageal carcinoma and 50 cases of cardiac carcinoma and their adjacent tissue. Results: The positive expression rates of P-gp were 2% and 2%, respectively in esophageal carcinoma and the adjacent tissue, while those for MRP were 76% and 42%; the positive expression rates of P-gp in cardiac carcinoma and the adjacent tissue were 54%, 30%, and those for MRP were 42% and 20%. The positive expression rate of MRP in esophageal carcinoma tissue and P-gp and MRP in cardiac carcinoma tissue were significantly higher than their adjacent tissue (P0.05). MRP was correlated with the differential degree of esophageal carcinoma and P-gp and MRP were correlated with the differential degree of cardiac carcinoma (P0.05). There was no relationship between the expression of P-gp and MRP in esophageal and cardiac carcinoma tissue (r_s=0.173, P0.05). Conclusion: MRP plays an important role in the primary MDR of esophageal carcinogenesis, and both P-gp and MRP contribute to the primary MDR of cardiac carcinoma. Their expression is associated with tumor cell differentiation, but not with the invasion depth and lymph node metastasis." @default.
- W2365488034 created "2016-06-24" @default.
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- W2365488034 date "2007-01-01" @default.
- W2365488034 modified "2023-09-24" @default.
- W2365488034 title "Expression of P-glycoprotein and multidrug resistance-associated protein in esophageal and cardiac carcinoma tissue" @default.
- W2365488034 hasPublicationYear "2007" @default.
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