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- W2365506413 abstract "AIM: To study the chemical constituents of the South China Sea sponge Biemna fortis to search for new bioactive substances. METHODS: The methanol extract of Biemna fortis Topsent was subjected to repeated silica gel column chromatographies to afford thirteen pure compounds (1-12), the structures of which were elucidated on the basis of detailed spectroscopic analysis and comparison with the data reported in the literature. RESULTS: Twelve known compounds were isolated and identified as melithasterol B (1), (24R)-ergosta-7,22-diene-3,5,6-triol (2), (24R)-ergosta-4,6,8(14), 22-tetraene-3-one (3), (24R)-ergosta-4,7,22-triene-3-one (4), (24R)-ergosta-6,22-diene-5,8-epidioxy-3-ol (5), 6-hydroxy-cho-lest-4-en-3-one (6), cholest-4-ene-3,6-dione (7), cholest-4-en-3-one (8), cholest-5,22-diene-3-one (9), bis-(2-ethylhexyl) phthalate (10), bis-diisobutyl phthalate (11) and hexaldehyde (12), respectively. CONCLUSION: Compounds 1-4, 5-10 and 12 were isolated from the examined sample for the first time. 7 exhibited significant T and B lymphocytes proliferation in-hibitory activity and significant hPTP1B inhibitory activity with IC50 1.6 mol·L 1." @default.
- W2365506413 created "2016-06-24" @default.
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- W2365506413 date "2008-01-01" @default.
- W2365506413 modified "2023-09-23" @default.
- W2365506413 title "Chemical Constituents of Marine Sponge Biemna fortis Topsent" @default.
- W2365506413 hasPublicationYear "2008" @default.
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