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- W2365508636 abstract "Objective:To investigate the protective effects and its mechanism of supplemental Sini San on hepatic fibrosis in rats.Method: The immunohepatic fibrosis model was induced by intraperitoneal injection of porcine serum.in to rats.Eighty Wister rats were divided into eight groups: normal control group,model control group,prevention group(7 g·kg-1),high dose group(14 g·kg-1),mediate dose group(7 g·kg-1),and low dose group(3.5 g·kg-1)of supplemental Sini San,colchicin control group(0.2 mg·kg-1),Sini San control group(4 g·kg-1).Except the normal control group,all the other groups were injected with pig serum without inactivation into abdominal cavity,twice per week and 0.5 mL each time,lasting 10 weeks.The prevention group was given supplemental Sini San,10 weeks at the same time when establishment of models began,the other groups were treated with correspoding drugs after 6 weeks of modelling,and lated 10 weeks.The changes of the biochemical indicator in serum and hepatic fibrosiswere were detected respectively.Result:Compared with model group,the serum content of alanine aminotransferase(ALT),aspartate aminotransferase(AST),r-glutamyl transpeptadase(GGT),alkaline phosphatase(ALP) and typeⅠ,Ⅲ,Ⅳcollage,hyaluronic acid(HA),laminin(LN) were depressed obviously,the content of hydroxyproline(HYP) in liver tissuewas significantly lower in supplemental Sini San mediatedose group.Conclusion: Supplemental Sini San has a treatment;action on hepatic fibrosis model rats." @default.
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- W2365508636 date "2012-01-01" @default.
- W2365508636 modified "2023-09-24" @default.
- W2365508636 title "Effects of Supplemental Sini San on Hepatic Function and Liver Fibrosisin in Rat Hepatic Fibrosis Model" @default.
- W2365508636 hasPublicationYear "2012" @default.
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