FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2365515521> ?p ?o ?g. }

• W2365515521 endingPage "4914" @default.
• W2365515521 startingPage "4905" @default.
• W2365515521 abstract "Abstract How the TCR repertoire, in concert with risk-associated MHC, imposes susceptibility for autoimmune diseases is incompletely resolved. Due largely to recombinatorial biases, a small fraction of TCRα or β-chains are shared by most individuals, or public. If public TCR chains modulate a TCRαβ heterodimer’s likelihood of productively engaging autoantigen, because they are pervasive and often high frequency, they could also broadly influence disease risk and progression. Prior data, using low-resolution techniques, have identified the heavy use of select public TCR in some autoimmune models. In this study, we assess public repertoire representation in mice with experimental autoimmune encephalomyelitis at high resolution. Saturation sequencing was used to identify &gt;18 × 106 TCRβ sequences from the CNSs, periphery, and thymi of mice at different stages of autoimmune encephalomyelitis and healthy controls. Analyses indicated the prominent representation of a highly diverse public TCRβ repertoire in the disease response. Preferential formation of public TCR implicated in autoimmunity was identified in preselection thymocytes, and, consistently, public, disease-associated TCRβ were observed to be commonly oligoclonal. Increased TCR sharing and a focusing of the public TCR response was seen with disease progression. Critically, comparisons of peripheral and CNS repertoires and repertoires from preimmune and diseased mice demonstrated that public TCR were preferentially deployed relative to nonshared, or private, sequences. Our findings implicate public TCR in skewing repertoire response during autoimmunity and suggest that subsets of public TCR sequences may serve as disease-specific biomarkers or influence disease susceptibility or progression." @default.
• W2365515521 created "2016-06-24" @default.
• W2365515521 creator A5000744610 @default.
• W2365515521 creator A5002881888 @default.
• W2365515521 creator A5013474566 @default.
• W2365515521 creator A5020088480 @default.
• W2365515521 creator A5037320538 @default.
• W2365515521 creator A5038115570 @default.
• W2365515521 creator A5046990774 @default.
• W2365515521 creator A5049579176 @default.
• W2365515521 date "2016-06-15" @default.
• W2365515521 modified "2023-09-27" @default.
• W2365515521 title "Preferential Use of Public TCR during Autoimmune Encephalomyelitis" @default.
• W2365515521 cites W1532919111 @default.
• W2365515521 cites W1547859938 @default.
• W2365515521 cites W1549080697 @default.
• W2365515521 cites W1618888036 @default.
• W2365515521 cites W1855466940 @default.
• W2365515521 cites W1943771969 @default.
• W2365515521 cites W1963745142 @default.
• W2365515521 cites W1968917486 @default.
• W2365515521 cites W1969632208 @default.
• W2365515521 cites W1976900976 @default.
• W2365515521 cites W1978391087 @default.
• W2365515521 cites W1979781154 @default.
• W2365515521 cites W1986354535 @default.
• W2365515521 cites W1989223689 @default.
• W2365515521 cites W2018975485 @default.
• W2365515521 cites W2024237661 @default.
• W2365515521 cites W2027372853 @default.
• W2365515521 cites W2033438397 @default.
• W2365515521 cites W2040547343 @default.
• W2365515521 cites W2042718212 @default.
• W2365515521 cites W2048659881 @default.
• W2365515521 cites W2060705027 @default.
• W2365515521 cites W2069778638 @default.
• W2365515521 cites W2094213517 @default.
• W2365515521 cites W2094800728 @default.
• W2365515521 cites W2097336904 @default.
• W2365515521 cites W2097490082 @default.
• W2365515521 cites W2098103958 @default.
• W2365515521 cites W2105381977 @default.
• W2365515521 cites W2108147510 @default.
• W2365515521 cites W2118852930 @default.
• W2365515521 cites W2119789840 @default.
• W2365515521 cites W2126216921 @default.
• W2365515521 cites W2130486201 @default.
• W2365515521 cites W2131248695 @default.
• W2365515521 cites W2132742682 @default.
• W2365515521 cites W2133621763 @default.
• W2365515521 cites W2143513209 @default.
• W2365515521 cites W2146074801 @default.
• W2365515521 cites W2147267371 @default.
• W2365515521 cites W2156506903 @default.
• W2365515521 doi "https://doi.org/10.4049/jimmunol.1501029" @default.
• W2365515521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4902001" @default.
• W2365515521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27183575" @default.
• W2365515521 hasPublicationYear "2016" @default.
• W2365515521 type Work @default.
• W2365515521 sameAs 2365515521 @default.
• W2365515521 citedByCount "34" @default.
• W2365515521 countsByYear W23655155212016 @default.
• W2365515521 countsByYear W23655155212017 @default.
• W2365515521 countsByYear W23655155212018 @default.
• W2365515521 countsByYear W23655155212019 @default.
• W2365515521 countsByYear W23655155212020 @default.
• W2365515521 countsByYear W23655155212021 @default.
• W2365515521 countsByYear W23655155212022 @default.
• W2365515521 countsByYear W23655155212023 @default.
• W2365515521 crossrefType "journal-article" @default.
• W2365515521 hasAuthorship W2365515521A5000744610 @default.
• W2365515521 hasAuthorship W2365515521A5002881888 @default.
• W2365515521 hasAuthorship W2365515521A5013474566 @default.
• W2365515521 hasAuthorship W2365515521A5020088480 @default.
• W2365515521 hasAuthorship W2365515521A5037320538 @default.
• W2365515521 hasAuthorship W2365515521A5038115570 @default.
• W2365515521 hasAuthorship W2365515521A5046990774 @default.
• W2365515521 hasAuthorship W2365515521A5049579176 @default.
• W2365515521 hasBestOaLocation W23655155211 @default.
• W2365515521 hasConcept C121332964 @default.
• W2365515521 hasConcept C147483822 @default.
• W2365515521 hasConcept C159654299 @default.
• W2365515521 hasConcept C19317047 @default.
• W2365515521 hasConcept C203014093 @default.
• W2365515521 hasConcept C207936829 @default.
• W2365515521 hasConcept C24890656 @default.
• W2365515521 hasConcept C2776090121 @default.
• W2365515521 hasConcept C2778473898 @default.
• W2365515521 hasConcept C2778486448 @default.
• W2365515521 hasConcept C2779075594 @default.
• W2365515521 hasConcept C2780130043 @default.
• W2365515521 hasConcept C2780640218 @default.
• W2365515521 hasConcept C54355233 @default.
• W2365515521 hasConcept C86803240 @default.
• W2365515521 hasConcept C8891405 @default.
• W2365515521 hasConceptScore W2365515521C121332964 @default.
• W2365515521 hasConceptScore W2365515521C147483822 @default.
• W2365515521 hasConceptScore W2365515521C159654299 @default.

• next