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- W2365528462 abstract "OBJECTIVE To optimize the formulation parameters of psoralen loaded hollow-bioadhesive microspheres.METHODS Box-behnken experimental design was employed to statistically optimize the formulation parameters of psoralen loaded hollow-bioadhesive microspheres.A three-factor,three-level design of experiment with response surface methodology was run to evaluate the main and interaction effect of several independent formulation variables that were included.RESULTS The optimized microspheres were obtained with a drug loading(Y1) of 9.18%,cumulative drug release in 6 h(Y2) of 76.15%,and spherisity(Y3) of80.97%,respectively.When the drug fed amount(X1),Ec∶Eu(X2),and PVA(X3) values were 12.36%,2.27 and 1.53%,respectively.CONCLUSION The results indicated Box-behnken experimental design facilitates the formulation and optimization of psoralen loaded hollow-bioadhesive microspheres." @default.
- W2365528462 created "2016-06-24" @default.
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- W2365528462 date "2013-01-01" @default.
- W2365528462 modified "2023-09-23" @default.
- W2365528462 title "Optimization of psoralen loaded hollow-bioadhesive microspheres formulation using Box-behnken experimental design" @default.
- W2365528462 hasPublicationYear "2013" @default.
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