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- W2365544219 abstract "OBJECTIVE To investigate the acute toxicity and major pharmacodynamic action of Folium Rhododendri Daurici dropping pills. METHODS LD50 was determined by means of oral administration to evaluate the acute toxicity. Animal models, such as strong ammonia induced cough in mice, citric acid induced cough in guinea pigs, phenolsulfonphthalein excretion from trachea in mice, were employed to evaluate the major pharmacodynamic action. RESULTS LD50 in mice of the effective fraction of the total flavonoids was 12.786 3 g·kg-1. The oral administration of Folium Rhododendri Daurici dropping pill significantly shortened cough delitescence, decreased cough frequency, increased sputum exclusion in mice at 70, 140 and 280 mg kg-1;shortened cough delitescence and decreased cough frequency in guinea pigs at 28, 56 and 112 mg kg-1, respectively. CONCLUSION Folium Rhododendri Daurici dropping pills have low acute toxicity with significant antitussive and eliminating phlegm activities." @default.
- W2365544219 created "2016-06-24" @default.
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- W2365544219 date "2008-01-01" @default.
- W2365544219 modified "2023-09-23" @default.
- W2365544219 title "Acute toxicity and major pharmacodynamics action of Folium Rhododendri Daurici dropping pills" @default.
- W2365544219 hasPublicationYear "2008" @default.
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