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- W2365559115 abstract "[Objective] to make a novel tumor vaccine with a new fusogenic liposome (FL) constructed with ultravioletinactivated Newcastle disease virus (NDV), and to study the immunological effect of the lymphcytes induced by the FL vaccine. [Methods] Unilamellar liposomes were prepared by the reverse-phase evaporation with some modification. The FL tumor vaccine was prepared with ultraviolet-inactivated NDV and unilamella liposomes which enwrapped the Hep-A-22 tumor soluble proteins. Then we detected the CTL effect of the FL tumor vaccine in vitro and inhibition of the tumor in vivo. [Results] The free protein antigen could not induce the reaction of cytotoxin of T lymphocyte. The FL vaccine can induce the cytotoxicity of the lymphocytes efficiently in vitro and inhibits the Hep-A-22 tumor growth greatly in viro, it had better inhibiting effect for tumor than NDV with tumor protein. [Conclusion] the FL vaccine prepared by NDV and unilamella liposome is a effective tumor vaccine carrier for treating and preventing cancer." @default.
- W2365559115 created "2016-06-24" @default.
- W2365559115 creator A5071915668 @default.
- W2365559115 date "2010-01-01" @default.
- W2365559115 modified "2023-09-22" @default.
- W2365559115 title "EXPERIMENTAL STUDY ON A NOVEL TUMOR VACCINE CONSTRUCTED WITH A NEW FUSOGENIC LIPOSOMES PREPARED WITH NEWCASTLE DISEASE VIRUS" @default.
- W2365559115 hasPublicationYear "2010" @default.
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