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- W2365584997 abstract "OBJECTIVE: To investigate the relationship beteween the expression of PTTG,VEGF,p53 and MVD and their role in occurance and development as well as their correlations to clinicopathologic features of colon rectal cancer.METHODS: The expression of PTTG,VEGF,p53 and CD34 was detected immunohistochemistrically in 18 cases of nomal colon tissue,20 cases of colon adenoma,44 cases of colon cancer.RESULTS: The positive rate of PTTG in normal colorectal tissues was 11.1%(2/18) and in colorectal adenomas and in colon cancer the positive rate were 75.0%(15/20),88.6%(39/44).The positive rate VEGF in normal colorectal tissues was 11.1%(2/18),while the positive expression rate in colorectal adenomas,colon cancer were of 40.0%(8/20),70.4%(31/44).p53 in normal colorectal tissue was negative expression,in colorectal adenomas and colon cancer positive expression rate were 50.0%(10/20),68.2%(30/44).Average density value of MVD in colon cancer was 67±26;while in the adenomas and normal colorectal tissues were 33±7 and 11±4.The espressions of PTTG,VEGF,p53 were significantly higher in colon cancer than that in nomal colon tissue and colon adenoma.In colon cancer the posive correlation existed between PTTG and VEGF(r=0.46,P0.05),between PTTG and p53(r=0.51,P0.05),between VEGF and p53(r=0.32,P0.05).CONCLUSIONS:PTTG,VEGF,p53 involved in the incidence of colon cancer,and up regulate tumor angiogenesis,promoting tumor invasion and metastasis.They can be used as a valid reference index of early diagnosis and prognosis for colorectal cancer." @default.
- W2365584997 created "2016-06-24" @default.
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- W2365584997 date "2012-01-01" @default.
- W2365584997 modified "2023-09-23" @default.
- W2365584997 title "Expression of pituitary tumor transforming gene,p53 and vascular endothelial growth factor in colon cancer and their meanings" @default.
- W2365584997 hasPublicationYear "2012" @default.
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