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- W2365588263 abstract "Whole cell voltage clamp recording technique was used to examine the effects of γ aminobutyric acid B receptor (GABA BR) activation on the neuronal activities in the substantia gelatinosa (SG) of rat spinal cord slice. Bath application of a GABA BR selective agonist, baclofen (10 μmol/L, 30 s), resulted in a frequency reduction of miniature excitatory postsynaptic currents (mEPSCs), together with a slow inhibitory (outward) membrane current in all tested SG neurons ( n =15). The membrane conductance of the SG neurons increased during the baclofen action. After the postsyanptic GABA BR being inhibited by intracellular G protein coupled receptor inhibitor GDP β S, the baclofen induced slow outward currents were depressed, while the effect of frequency reduction on mEPSCs persisted. The results indicate that activation of baclofen sensitive GABA BR in spinal cord directly hyperpolarizes SG neurons, and can presynaptically reduce neurotransmitter release." @default.
- W2365588263 created "2016-06-24" @default.
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- W2365588263 date "2001-01-01" @default.
- W2365588263 modified "2023-09-25" @default.
- W2365588263 title "Inhibitory effects of baclofen upon substantia gelatinosa neurons in rat spinal cord slice" @default.
- W2365588263 hasPublicationYear "2001" @default.
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