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- W2365589718 abstract "Objective:To investigate the correlation between C-erbB-2,nm23 gene expression and histological classfication,clinical stage,lymph node metastasis in breast cancer.Methods:The SP immunohistochemical method was used in 98 paraffin-embeded postoperative samples from breast cancer.Results:The rate of C-erbB-2 gene expression was 60.29% in lymph node metastases group and 33.33% in non-metastases group,there was a significant difference between the two groups.The C-erbB-2 expression was 77.78% in clinical stage Ⅳ,56.60% in Ⅱb+Ⅲ,25.92% in Ⅰ+Ⅱ a ,respectively and there was also a significant difference in the three stages.C_erbB_2 was overexpressed in ductal infiltrating cancer (83.33%)and parenchymal cancer(64.41%).The rate of nm23 gene expression was 39.71% in lymph node metastases group and 76.67% in non-metastases group,there was a significant difference in the two groups.Conclusion:The positive expression of C-erbB-2 gene was associated with histological classification and positively correlated with lymph node metastasis and clinical stage.Positive nm23 gene expression was inversely correlated with lymph node metastasis,but not related with histological classification and clinical stage." @default.
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- W2365589718 title "The study of C-erbB-2 and nm23 expression in breast cancer" @default.
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