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- W2365617612 abstract "Objective To investigate the changes of expression of neuronal nitric oxide synthase(nNOS) after sleep deprivation(SD) in rats,and to study the effects of Xingnaojing on them. Methods Rapid eye movement(REM) SD models(SD group,n=40) were established by the modified multiple platform methods.The rats in SD group were subjected to drug intervention group(n=20) and non-drug intervention group(n=20).Xingnaojing injection was administered to the drug intervention group.Rats in SD group were deprived of sleep for 1,3,5 and 7 d. The expression of nNOS in brain tissues was detected by immunohistochemistry.The rats without SD were severed as cage control group(n=10) and tank control group(n=10). Results The expression of positive cells of nNOS in brain tissues increased with the time of SD,and Xingnaojing decreased the number of positive cells of nNOS.The area density of positive reaction cells in SD group was significantly higher than those in cage control group and tank control group(P0.01).The area density of positive reaction cells in drug intervention group was significantly lower than that in non-drug intervention group(P0.01). Conclusion REM SD can lead to the increase of nNOS expression,which may result in the increase of nitric oxide,and ultimately bring toxicity effects to neuron cells.Xingnaojing injection exerts cerebral protective effects against REM SD through the mechanism of decreasing nNOS expression." @default.
- W2365617612 created "2016-06-24" @default.
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- W2365617612 date "2008-01-01" @default.
- W2365617612 modified "2023-09-24" @default.
- W2365617612 title "Changes of expression of neuronal nitric oxide synthase after sleep deprivation and effects of Xingnaojing on them" @default.
- W2365617612 hasPublicationYear "2008" @default.
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